Set in near-future inland Florida, Teenage Euthanasia centers around the owners of Tender Endings funeral home, the Fantasy Family: Grandma Baba, her adult children Uncle Pete and Trophy, and Trophy's teenage daughter, Euthanasia ("Annie"), a name accidentally given to her during the time of Trophy's own unbearable suffering. Back when Trophy was a teen herself; she ran away from home after giving birth to Annie, leaving her newborn to be raised by Baba and Uncle Pete. Now, 15 years later, Trophy returns to Tender Endings...as a corpse, for burial. When a bolt of lightning strikes Baba's homemade embalming fluid and one of Annie's tears, Trophy comes back from the dead. As a resurrected woman, Trophy has a variety of quasi-useful death powers. But more importantly, she has a second chance at unplanned parenthood.

　　一对年轻的布鲁克林夫妇前往北部，他们断开了手机，与自己重新建立联系。由于切断了电子设备，他们错过了地球正遭受攻击的消息。

　　中年单身程序设计师马特决定要当父亲，通过面试找到26岁的咖啡店服务生安娜代孕生子。安娜因与家人关系僵化，搬至旧金山，她希望通过代孕能获得供自己完成学业的钱。在孕期马特积极介入安娜的生活，事无巨细，安娜也逐渐接受马特的亲密，彼此敞开心扉，建立了一段不太寻常的友谊。